CAS NO.:72968-50-4
Active Ingredient: Hesperidin 98%
Sieve Analysis: 100% through 80 mesh
Test Method: HPLC
Bitter Orange Extract description
Introduction:
Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition, it contributes to the integrity of the blood vessels.
Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects. Hesperidin is also a sedative, possibly acting through opioid or adenosine receptors.
Some in vitro results applied only to the aglucone form. Hesperidin also showed the ability to penetrate the blood brain barrier in an in vitro model.
Functions:
- Hesperidins has antioxidant, anti-inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions.
- Hesperidins can inhibit following enzymes: Phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase.
- Hesperidins improve the health of capillaries by reducing the capillary permeability.
- Hesperidins are used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anti-cancer activity of hesperidins could be explained by the inhibition of polyamine synthesis.
