Description
Estradiol cypionate (Depo-Estradiol, Depofemin, Estradep, many others), or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4-5 days and 7-8 days, respectively.
This medication is a female hormone (estrogen). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).
Estradiol is a hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.
The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.
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