Title: Pregabalin intermediates
CAS Registry Number: 148553-50-8
CAS Name: (3S)-3-(Aminomethyl)-5-methylhexanoic acid
Additional Names: (S)-(+)-4-amino-3-(2-methylpropyl)butanoic acid; (S)-(+)-3-isobutyl-g-aminobutyric acid
Manufacturers' Codes: CI-1008; PD-144723
Molecular Formula: C8H17NO2
Molecular Weight: 159.23.
Percent Composition: C 60.34%, H 10.76%, N 8.80%, O 20.10%
Properties: White crystalline solid, mp 186-188? [a]D23 +10.52?(c = 1.06 in water).
Melting point: mp 186-188°
Optical Rotation: [a]D23 +10.52?(c = 1.06 in water)
Therap-Cat: Anticonvulsant.
Pregabalin, is a new type of GABA receptor agonists, can block the voltage dependence calcium channel to reduce the neurotransmitter release, mainly used for clinical treatment of peripheral neuropathy and auxiliary for the treatment of localized part seizures.
